Biomedicine
From Code to Cure
Antigen Solubility Engineering
Design a soluble analog of a multi-pass transmembrane protein while maintaining its extracellular structure and immunogenic properties with generative AI.
90% designs are expressive, soluble and thermostable
Merely 22% sequence similarity in the TM regions
De Novo Antibody Design
Multiple low-nanomolar antibody/nanobody candidates have been identified via our de novo design and high-throughput screening pipeline.
Highly novel, patentable sequences
Binds to the specified epitope on the desired conformation
Functional Protein Design
In this example project we redesigned the target-binding loop to produce patentable analogs.
Among the 100 candidates generated in the first round:
80% can be expressed and have good thermostability
50% showed higher target-binding affinity (up to ~100 pM) than the benchmark