中文BioGeometry has successfully completed a protein engineering project for a key IVD reagent enzyme, delivering results to Nanjing Novozan Biotechnology Co., Ltd. The redesigned enzyme showed unprecedented improvements—surpassing all known public records and industrial standards.
Closing Industry Gaps: GeoFlow V2 Tackles Enzyme Performance Challenges
Powered by BioGeometry’s cutting-edge atomic-level protein model GeoFlow V2, the project addressed a long-standing challenge: improving enzyme activity under specific saline ion concentrations. Until now, no effective solutions had been reported in this area. The redesigned enzyme not only met stringent quality requirements but also delivered robust performance.
In just 60 days and through three iterative design rounds, the optimized enzyme boosted product yield by over 21 times under targeted saline conditions—dramatically increasing manufacturing efficiency.
Additionally, the engineered enzyme maintained (or exceeded) the wild-type enzyme in key metrics such as specific activity, stability, and product purity.
From Lab to Industry: Toward Deeper Collaboration
GeoFlow V2 enabled a 20-fold performance leap in just two months—bridging a critical technical gap where no prior solution existed. This achievement highlights the speed, precision, and potential of generative AI in industrial enzyme optimization.
BioGeometry integrated multiple design constraints – including product yield, reaction conditions, stability, and patent considerations – into its approach. Using a reinforcement learning framework, the model dynamically balanced these competing objectives, ensuring the protein design fit seamlessly within the full industrial workflow. The result is not just an isolated performance gain, but a holistic solution tailored for real-world production needs.
Looking ahead, BioGeometry will continue expanding GeoFlow’s applications across diagnostics, therapeutics, and vaccine development, partnering with industry leaders to accelerate the scalable future of biomanufacturing.